Project Title: Non-inferiority assessment of Pyretroid-PBO nets
Project Description: We propose to evaluate the five PQ Listed pyrethroid-PBO ITNs. The evaluation will have two phases. First phase, a regeneration time evaluation to calculate the correct wash interval for the pyrethroid-PBO nets that captures the regeneration time of the PBO, specifically. This is done using a susceptible and a metabolic resistant mosquito strain. Second phase, an experimental hut evaluation of the five pyrethroid-PBO ITNs in an area of intermediate pyrethroid resistance due to metabolic resistance... We propose to evaluate the five PQ Listed pyrethroid-PBO ITNs. The evaluation will have two phases. First phase, a regeneration time evaluation to calculate the correct wash interval for the pyrethroid-PBO nets that captures the regeneration time of the PBO, specifically. This is done using a susceptible and a metabolic resistant mosquito strain. Second phase, an experimental hut evaluation of the five pyrethroid-PBO ITNs in an area of intermediate pyrethroid resistance due to metabolic resistance (overexpression of CYP450). The study is powered to detect non-inferiority of second in class PQ listed pyrethroid-PBO ITNs to the first-in-class product (Olyset® Plus) and superiority over the standard comparator, a well characterised and highly efficacious pyrethroid only ITN (PermaNet ® 2.0). The design will be four partially randomised Latin Square designs run in parallel (7 x 7 x 4 William’s Latin Square design), using 28 huts. Seven volunteers are assigned to each of four blocks of seven huts. On each night, each treatment condition will be replicated in two huts. Volunteers will rotate through the huts each night and after 7 nights the treatments will be rotated. Study sample size will be 98 nights per treatment condition i.e. 7 x 7 x 2. The primary outcomes that will be measured are mortality and feeding inhibition. Other secondary outcomes, deterrence and exophily will also be measured. The proposed duration for the phase I is 4 months, experimental hut study is 3 months, 2 months for post experimental hut study WHO Cone bioassay and 2 months for data analysis and report writing, approximately one year sufficient to complete the study.
Principal Investigator : Sarah Moore
Department Name : EHES
Time frame: (2020-01-06) - (2020-12-31)
The Global Fund (Normal)
External Collaborating Partners
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